To : Yoshinori Ohsumi ( japan
)
(for his discoveries
of mechanisms for autophagy)
Summary :
·
This year's Nobel Laureate discovered
and elucidated mechanisms underlying autophagy,
a fundamental process for degrading and recycling
cellular components.
·
It is a crucial process. During
starvation, cells break down proteins and nonessential components and reuse
them for energy. Cells also use autophagy to destroy invading viruses and
bacteria, sending them off for recycling. And cells use autophagy to get rid of
damaged structures.
·
The word autophagy originates from the Greek words auto-, meaning "self", and phagein, meaning "to eat".
·
Thus,autophagy denotes "self
eating". This concept emerged during the 1960's, when researchers first
observed that the cell could destroy its own contents by enclosing it in
membranes, forming sack-like vesicles that were transported to a recycling
compartment, called the lysosome, for degradation.
·
Difficulties in studying the phenomenon
meant that little was known until, in a series of brilliant experiments in the
early 1990's, Yoshinori Ohsumi used baker's yeast to identify genes essential
for autophagy.
·
He then went on to elucidate the
underlying mechanisms for autophagy in yeast and showed that similar
sophisticated machinery is used in our cells.
·
Ohsumi's discoveries led to a new
paradigm in our understanding of how the cell recycles its content.
·
His discoveries opened the path to
understanding the fundamental importance of autophagy in many physiological
processes, such as in the adaptation to starvation or response to infection.
·
Mutations in autophagy genes can cause
disease, and the autophagic process is involved in several conditions including
cancer and neurological disease.
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